| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P | 38 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | HTRA2/Omi Rabbit Monoclonal Antibody detects endogenous levels of HTRA2/Omi protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HTRA2 also known as Omi is a member of the serine protease family. HTRA2 plays a crucial role in cellular stress responses by degrading misfolded proteins, thereby preventing the accumulation of potentially toxic aggregates. HTRA2 is predominantly localized in the mitochondria and is involved in regulating apoptosis, making HTRA2 essential for maintaining cellular homeostasis. HTRA2 is expressed in various tissues, including the kidney, colon, and thyroid, and HTRA2 expression is tightly regulated; alterations in HTRA2 levels have been implicated in several diseases, including neurodegenerative disorders and cancer. HTRA2 exists in two polypeptide forms and features a modified PDZ domain that influences HtrA2 interactions with other proteins, such as the Mxi2 protein, which is not recognized by the alternatively spliced D-Omi form. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, MCF7, Jurkat cells, using HTRA2/Omi Rabbit Monoclonal Antibody (EAB22602) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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