| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC, FC | 18 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-1:100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | α/β-Synuclein Rabbit Monoclonal Antibody detects endogenous levels of α/β-Synuclein protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
α/β-synuclein also known as SNCA/SNCB are presynaptic proteins predominantly expressed in the brain, where they play crucial roles in synaptic regulation and neuronal plasticity. Nitration is a significant post-translational modification of α-synuclein that is implicated in the pathogenesis of neurodegenerative diseases like Parkinson′s disease, as nitration affects protein aggregation and toxicity. α-Synuclein interacts with several key proteins, including synphilin-1, which contributes to the formation of Lewy bodies, and Parkin, an E3 ubiquitin ligase involved in protein degradation pathways. β-Synuclein interacts with proteins such as tau, which is important in Alzheimer′s disease, highlighting β-synuclein′s role in neuronal health. Nitration of these synucleins alters interactions with binding partners, thereby influencing function and contributing to disease progression. |
| Product Image Gallery | |
 Western blot analysis of extracts on Mouse brain, Rat brain cells, using α/β-Synuclein Rabbit Monoclonal Antibody (EAB21569) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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