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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P | 36 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-200 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IgG4 Rabbit Monoclonal Antibody detects endogenous levels of IgG4 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IgG4 also known as IGHG4 is a unique subclass of immunoglobulin G that plays a crucial role in the immune response, particularly in modulating allergic reactions and autoimmune diseases. Unlike other IgG subclasses, IgG4 is known for its ability to undergo a process called "Fab-arm exchange," which allows IgG4 to form bispecific antibodies that can bind to two different antigens simultaneously. This characteristic is significant as IgG4 can help in regulating immune responses and reducing inflammation, making IgG4 an important player in maintaining immune tolerance. Furthermore, research has indicated that low concentrations of IgG4 are often found in patients with recurrent respiratory tract infections, suggesting IgG4′s potential role in immune system dysfunction. |
| Product Image Gallery | |
 Western blot analysis of extracts on Human plasma, Human spleen cells, using IgG4 Rabbit Monoclonal Antibody (EAB21560) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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