| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 47 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | β-Arrestin 1 Rabbit Monoclonal Antibody detects endogenous levels of β-Arrestin 1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
β-Arrestin 1 is a key member of the arrestin protein family, playing a crucial role in regulating G protein-coupled receptor (GPCR) signaling by mediating receptor desensitization and internalization. Structurally, β-Arrestin 1 consists of two distinct domains: the N-terminal domain and the C-terminal domain, which together form a bilobal structure that facilitates interaction with phosphorylated GPCRs and other signaling proteins. This structural arrangement is essential for β-Arrestin 1′s ability to scaffold various signaling complexes, thereby modulating diverse cellular responses such as hormone signaling, neurotransmission, and sensory perception. The precise three-dimensional conformation of β-Arrestin 1 allows effective binding to activated receptors, preventing continuous G protein activation and enabling receptor recycling or degradation. |
| Product Image Gallery | |
 Western blot analysis of extracts on PC12, Jurkat cells, using β-Arrestin 1 Rabbit Monoclonal Antibody (EAB22180) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 47 kDa; Observed band size: 50 kDa  Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue, using β-Arrestin 1 Rabbit Monoclonal Antibody (EAB22180) at 1:100 dilution.
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