| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC | 69 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ASH2L Rabbit Monoclonal Antibody detects endogenous levels of ASH2L protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ASH2L features a nuclear localization signal and a PHD finger motif, indicating a role as a transcriptional regulator. ASH2L is involved in gene expression regulation during early development, with a Drosophila homolog, ash2, playing a similar role. ASH2L′s structure, particularly the PHD finger motif, facilitates interactions with histone modifications, influencing chromatin dynamics and gene transcription. Alternative splicing of ASH2L gene results in a shorter isoform, ASH2L2, which lacks the first 94 amino acids of ASH2L1, potentially altering functional properties. ASH2L expression patterns in response to differentiation inducers, such as phorbol ester and hemin, suggest a significant role in hematopoiesis and association with certain types of leukemia, making ASH2L a valuable target for research in cancer biology and developmental processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on PC12, 293T cells, using ASH2L Rabbit Monoclonal Antibody (EAB22492) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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