| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 45 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Cathepsin D Rabbit Monoclonal Antibody detects endogenous levels of Cathepsin D protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Cathepsin D also known as CPSD, CTSD is a member of the A1 family of peptidases. Cathepsin D plays a crucial role in studying cellular metabolism, autophagy, and apoptosis by detecting proteins broken down into smaller peptides within the acidic lysosomal environment. This enzyme is synthesized as an inactive precursor and activated through proteolytic cleavage, which is essential for enzymatic activity. Cathepsin D also cleaves specific protein precursors to release regulatory peptides that modulate various cellular processes. Enzymatic activity is tightly regulated, as dysregulation has been implicated in pathological conditions, including cancer, where cathepsin D may promote tumor progression and metastasis. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7, Jurkat cells, using Cathepsin D Rabbit Monoclonal Antibody (EAB22060) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 45 kDa; Observed band size: 28,46 kDa |
