| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, FC | 100 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | LGR5 Rabbit Monoclonal Antibody detects endogenous levels of LGR5 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LGR5 also known as GRP49 is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. LGR5 is a 907 amino acid multi-pass membrane protein characterized by 17 leucine-rich repeats, which are crucial for structural integrity and function as a G protein-coupled receptor. LGR5 protein is predominantly expressed in placenta, skeletal muscle, and spinal cord, where LGR5 plays a vital role as an orphan receptor involved in embryonic growth control and cellular differentiation. The significance of LGR5 extends beyond normal physiological processes; LGR5 overexpression has been linked to increased tumor susceptibility and malignant transformation, highlighting LGR5′s potential as a key player in cancer biology. |
| Product Image Gallery | |
 Western blot analysis of extracts on SH-SY5Y cells, using LGR5 Rabbit Monoclonal Antibody (EAB21488) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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