| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 93 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Caldesmon Rabbit Monoclonal Antibody detects endogenous levels of Caldesmon protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caldesmon also known as CDM, CALD1 is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. Caldesmon is essential for maintaining the structural integrity of the cytoskeleton and facilitating muscle function. Caldesmon exists in two main forms: muscular Caldesmon, predominantly found in smooth muscle, and non-muscular Caldesmon, which is expressed in various non-muscle tissues. The gene encoding Caldesmon undergoes alternative splicing, resulting in five isoforms, each with distinct regulatory roles. Muscular Caldesmon, also known as high molecular weight Caldesmon or H-Caldesmon, is primarily located on thin filaments in smooth muscle, while the non-muscular isoforms (2-5), referred to as low molecular weight Caldesmon or L-Caldesmon, are widely distributed in non-muscle cells. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, NIH/3T3 cells, using Caldesmon Rabbit Monoclonal Antibody (EAB21450) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 93 kDa; Observed band size: 70 kDa  Immunohistochemical analysis of paraffin-embedded Human kidney tissue, using Caldesmon Rabbit Monoclonal Antibody (EAB21450) at 1:100 dilution.
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