| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IF/ICC | 131 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Jak2 Rabbit Monoclonal Antibody detects endogenous levels of Jak2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Jak2(Janus kinase 2) is a vital member of the non-receptor Janus tyrosine kinase family, integral to the JAK/STAT signaling pathway that regulates essential cellular functions including proliferation, differentiation, and survival within the immune and hematopoietic systems. Upon activation by cytokines and interferons, JAK2 phosphorylates STAT transcription factors, which then dimerize and migrate to the nucleus to modulate gene expression. This signaling mechanism is crucial for maintaining immune homeostasis and orchestrating responses to pathogens. Dysregulation of JAK2 activity is associated with various inflammatory diseases and cancers, highlighting JAK2′s importance as a therapeutic target. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, 293 cells, using Jak2 Rabbit Monoclonal Antibody (EAB21458) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
