| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 128 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CD11c Rabbit Monoclonal Antibody detects endogenous levels of CD11c protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CD11c also known as Integrin αX, ITGAXi s a type 1 transmembrane protein that plays a crucial role in the immune response by forming a leukocyte-specific integrin when combined with the β2 chain, known as the inactivated-C3b receptor 4 (CR4). This integrin is essential for mediating the adherence of neutrophils and monocytes to activated endothelial cells, as well as facilitating the phagocytosis of complement-coated particles. CD11c enables dendritic cells, macrophages, and natural killer cells to migrate to lymphoid tissues and interact with T and B cells, thereby shaping the adaptive immune response. Abnormal expression of CD11c is associated with hairy cell leukemia, highlighting its significance in both normal immune function and disease states. |
| Product Image Gallery | |
 Western blot analysis of extracts on THP-1 cells, using CD11c Rabbit Monoclonal Antibody (EAB22728) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 128 kDa; Observed band size: 145 kDa |
