| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IF/ICC | 90 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IF/ICC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | HSP90α Rabbit Monoclonal Antibody detects endogenous levels of HSP90α protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HSP90 plays a crucial role as a molecular chaperone, assisting in proper folding and stabilization of numerous client proteins, including steroid hormone receptors and kinases, which are vital for cellular signaling and stress responses. This chaperoning function helps maintain cellular homeostasis and protects cells from stress-induced damage, thereby influencing processes such as cell growth, differentiation, and apoptosis. HSP90 forms complexes with various proteins, including glucocorticoid receptor, which is rendered transcriptionally inactive in the absence of ligand, highlighting HSP90′s role in regulating gene expression. HSP90′s ability to interact with a diverse array of proteins underscores HSP90′s significance in cellular function and potential as a therapeutic target in diseases characterized by protein misfolding and aggregation. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Jurkat, HepG2, MCF7 cells, using HSP90α Rabbit Monoclonal Antibody (EAB21423) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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