| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 43 | Human, Mouse, Rat, Chicken |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MEK1 Rabbit Monoclonal Antibody detects endogenous levels of MEK1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MEK1 also known as MKK1, MAP2K1 is a member of the dual specificity protein kinase family. MEK1 plays a crucial role in the MAPK signaling pathway, which is essential for regulating various cellular processes such as proliferation, differentiation, and survival. MEK1 is primarily located in the cytoplasm and is activated in response to growth factors and other extracellular signals, leading to translocation to the nucleus where MEK1 phosphorylates and activates extracellular signal-regulated kinases (ERKs). This activation is vital for the transmission of signals from the cell surface to the nucleus, ultimately influencing gene expression and cellular responses. MEK1 interaction with other proteins in the MAPK pathway, such as RAS and RAF, underscores MEK1′s importance in cellular signaling and potential implications in cancer and other diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on A431, Jurkat, Mouse skin cells, using MEK1 Rabbit Monoclonal Antibody (EAB21304) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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