WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Prohibitin 1 also known as PHB1 is an evolutionarily conserved protein that plays a crucial role in regulating the cell cycle, particularly by inhibiting the G1 to S phase transition, which helps maintain proper cellular proliferation and prevent uncontrolled growth. Prohibitin primarily localizes in the inner mitochondrial membrane, where this protein contributes to mitochondrial function and acts as a tumor suppressor by interacting with retinoblastoma protein and inhibiting E2F transcription factors in response to specific signaling pathways. Prohibitin also participates in B cell maturation at the plasma membrane, demonstrating diverse roles in cellular processes. Mutations in Prohibitin genes have been linked to breast cancer development and progression in over 80% of analyzed cell lines, highlighting significant implications in cancer biology.