| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 51 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Caspase-2 Rabbit Monoclonal Antibody detects endogenous levels of Caspase-2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caspase-2 also knonw as CASP2 is a member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is an aspartate-specific cysteine protease that plays a crucial role in the apoptotic process, being activated in response to various apoptotic stimuli. Caspase-2 is unique among caspases due to its dual characteristics, possessing features of both upstream caspases, with a long prodomain, and downstream caspases, with DEXD substrate specificity. Notably, caspase-2 is predominantly expressed in the brain during development and is found at lower levels in adult tissues. Caspase-2 is localized in several cellular compartments, including the mitochondria, Golgi apparatus, cytoplasm, and nucleus, which is significant as localization is essential for its role in apoptosis regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293, Jurkat cells, using Caspase-2 Rabbit Monoclonal Antibody (EAB21353) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 51 kDa; Observed band size: 48, 30, 12 kDa |
