| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC, FC | 68 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-100 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SHP-1 Rabbit Monoclonal Antibody detects endogenous levels of SHP-1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SHP-1 also known as SH-PTP1, PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. SHP-1 plays a crucial role in regulating cellular signaling pathways by dephosphorylating tyrosine residues on target proteins, which is essential for maintaining the balance of tyrosine phosphorylation in cells. This regulation is particularly important in hematopoietic cells, where SHP-1 modulates the activity of various signaling pathways involved in cell growth, differentiation, and immune responses. The presence of two SH2 domains in SHP-1 enables interaction with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby influencing the downstream signaling events that are critical for cellular function. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Jurkat, Raw264.7 cells, using SHP-1 Rabbit Monoclonal Antibody (EAB22576) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:10000 dilution.
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