| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 43, 44 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MEK1/2 Rabbit Monoclonal Antibody detects endogenous levels of MEK1/2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MEK1 also known as MKK1, MAP2K1 and MEK2 also known as MKK2, MAP2K2 are dual specificity protein kinase that belongs to the MAP kinase kinase family. MEK1 and MEK2 play a crucial role in the mitogen-activated protein kinase (MAPK) signaling pathway, essential for various cellular processes, including proliferation, differentiation, and survival. MEK1 and MEK2 proteins are located in the cytoplasm and activate in response to extracellular signals, leading to phosphorylation of downstream MAP kinases such as ERK. Proper functioning of MEK1 and MEK2 remains vital, as dysregulation of this pathway can contribute to various diseases, including cancer. MEK1 and MEK2 interact with other proteins in the signaling cascade, such as Raf kinases, further underscoring their importance in cellular signaling networks. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562 cells, using MEK1/2 Rabbit Monoclonal Antibody (EAB21436) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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