| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 54 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MMP-1 Rabbit Polyclonal Antibody detects endogenous levels of MMP-1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MMP-1(Matrix metallopeptidase 1) is a member of the peptidase M10 family of matrix metalloproteinases (MMPs). MMP-1 plays a critical role in degrading extracellular matrix components such as collagen, gelatin, fibronectin, laminin, and proteoglycans, which is essential for processes like tissue remodeling, wound healing, and angiogenesis. By breaking down these matrix proteins, MMP-1 facilitates cellular migration and invasion, making MMP-1 a key player in both normal physiological and pathological conditions, including cancer metastasis and rheumatoid arthritis. The regulation of MMP-1 is intricately linked to cellular signaling pathways, where p53 downregulates MMP-1, highlighting MMP-1′s importance in maintaining cellular homeostasis and preventing excessive tissue degradation. MMP-1 requires calcium and zinc ions for catalytic activity, which is characteristic of the matrix metalloproteinase family. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, 293T, NIH/3T3 cells, using MMP-1 Rabbit Polyclonal Antibody (EAB10162) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Western blot analysis of extracts on Jurkat, K562 cells, using MMP-1 Rabbit Polyclonal Antibody (EAB10162) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using MMP-1 Rabbit Polyclonal Antibody (EAB10162) at 1:200 dilution.
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