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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, ELISA | 42 | Human |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | HDAC8 Mouse Monoclonal antibody detects endogenous levels of HDAC8 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HDAC8(Histone deacetylase 8) is a member of the histone deacetylase family. HDAC8 is primarily located in the nucleus and plays a crucial role in the regulation of gene expression through the modification of chromatin structure. By removing acetyl groups from lysine residues on histones, HDAC8 contributes to the condensation of chromatin, leading to transcriptional repression. This process is vital for maintaining cellular homeostasis and regulating developmental processes, as aberrant HDAC activity has been implicated in various cancers and other diseases. HDAC8 interacts with several other proteins, including transcription factors and co-repressors, which further modulates gene regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, MCF7, HepG2 cells, using HHDAC8 Mouse Monoclonal antibody (EAB22575) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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