| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 59 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | KAT5/Tip60 Rabbit Polyclonal Antibody detects endogenous levels of KAT5/Tip60 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TIP60 also known as KAT5 is a crucial chromatin-associated protein that functions as a histone acetyltransferase (HAT), playing a significant role in the regulation of gene expression and chromatin remodeling. TIP60 recognizes a protein that modifies histones through acetylation, which alters chromatin structure and accessibility, thereby influencing transcriptional activation. TIP60 is particularly notable for its interactions with various transcriptional coactivators and nuclear hormone receptors, enhancing the transcriptional response to steroid hormones such as androgens, estrogens, and progestins. Additionally, TIP60 has been implicated in DNA damage response pathways, where TIP60 acts as a coactivator for the HIV TAT protein and is involved in the recruitment of repair factors to sites of DNA damage. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3, Mouse brain cells, using KAT5/Tip60 Rabbit Polyclonal Antibody (EAB14628) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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