| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 108 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CSF-1R/c-Fms Rabbit Polyclonal Antibody detects endogenous levels of CSF-1R/c-Fms protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CSF-1R/c-Fms also known as M-CSFR, CD115 is a transmembrane tyrosine kinase receptor. CSF-1R/c-Fms plays a crucial role in the growth and differentiation of myeloid cells. CSF-1R/c-Fms is encoded by the c-Fms proto-oncogene and is predominantly expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells, and certain myoblasts. CSF-1R/c-Fms mediates the functions of M-CSF, a glycoprotein essential for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF is a significant player in the inflammatory response, regulating the release of pro-inflammatory cytokines from macrophages, thereby influencing immune responses and tissue homeostasis. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T, HT29 cells, using CSF-1R/c-Fms Rabbit Polyclonal Antibody (EAB14448) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 108 kDa; Observed band size: 110-200 kDa |
