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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 39 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-MKK3 (Ser189) Rabbit Polyclonal Antibody detects endogenous levels of MKK3 only when phosphorylated at Ser189. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MKK3 also known as MEK3, MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MKK3 plays a crucial role in the activation of the p38 MAP kinase pathway, which is essential for cellular responses to stress and inflammation. By phosphorylating specific threonine and tyrosine residues on p38 MAP kinase, MKK3 facilitates the transmission of signals that regulate various biological processes, including cell differentiation, apoptosis, and the immune response. The importance of MKK3 in these pathways highlights MKK3′s potential as a therapeutic target in diseases characterized by dysregulated MAP kinase signaling, such as cancer and inflammatory disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using Phospho-MKK3 (Ser189) Rabbit Polyclonal Antibody (EAB11919) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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