www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 48 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Skp2 (Ser64) Rabbit Polyclonal Antibody detects endogenous levels of Skp2 protein only when phosphorylated at Ser64. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Skp2 also known as Skp2 p45 is a member of the F-box protein family. Skp2 plays a pivotal role in regulating cell cycle progression, particularly in G1 to S phase transition, by targeting specific cyclins for degradation. Skp2 primarily resides in the nucleus, interacting with cyclin-dependent kinases and other regulatory proteins to facilitate timely cell cycle progression. Precise nuclear localization of Skp2 enables effective regulation of cyclin levels, maintaining cellular homeostasis and preventing uncontrolled cell proliferation. Dysregulation of Skp2 has been implicated in various cancers, highlighting Skp2′s importance as a potential therapeutic target. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293 cells, using Phospho-Skp2 (Ser64) Rabbit Polyclonal Antibody (EAB10853) at 1:500 dilution. The lane on the left is blocked with the phospho peptide.
|
