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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 84 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-GIT2 (Tyr392) Rabbit Polyclonal Antibody detects endogenous levels of GIT2 protein only when phosphorylated at Tyr392. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GIT2 is a member of the GIT protein family. GIT2 plays a crucial role in the regulation of G protein-coupled receptor signaling by acting as a GTPase-activating protein for members of the ADP ribosylation factor family, which are essential for vesicular trafficking. GIT2 helps modulate the internalization and resensitization of receptors, thereby influencing cellular responses to external signals. Notably, GIT2 interacts with various proteins, including GIT1, which can impact the dynamics of receptor signaling pathways. By facilitating the inactivation of G protein-coupled receptors, GIT2 ensures that cells can effectively respond to stimuli without becoming overstimulated, highlighting GIT2′s importance in maintaining cellular homeostasis and signaling fidelity. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells, using Phospho-GIT2 (Tyr392) Rabbit Polyclonal Antibody (EAB10773) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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