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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 57 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | FRS2 Rabbit Polyclonal Antibody detects endogenous levels of FRS2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
FRS2 also known as SNT, FRS2alpha is a lipid-anchored docking protein that becomes tyrosine phosphorylated in response to FGF or NGF stimulation and subsequently binds to GRB2/Sos complexes. FRS2 plays a pivotal role as a docking protein in the FGF and NGF signaling pathways, essential for the activation of the Ras/MAPK pathway by bridging receptor tyrosine kinases to key signaling molecules like GRB2 and SOS. Located primarily at the plasma membrane, the subcellular localization of FRS2 is crucial for its function in signal transduction, facilitating effective interactions with activated receptors. Structurally, FRS2 is characterized by four Grb2 binding sites, a myristylation sequence necessary for membrane anchoring, and a protein tyrosine phosphatase (PTP) domain, all of which are vital for its interactions and signaling capabilities. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells, using FRS2 Rabbit Polyclonal Antibody (EAB10768) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 57 kDa; Observed band size: 65-85 kDa |
