| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IF/ICC, ELISA | 64 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Dab1 (Tyr232) Rabbit Polyclonal Antibody detects endogenous levels of Dab1 protein only when phosphorylated at Tyr232. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Dab1 also known as SCA37 is a homolog of the Drosophila Disabled protein. Dab1 plays a crucial role as an adaptor protein in neural development, particularly during the rapid expansion of the developing nervous system. Located primarily in the cytoplasm, Dab1 undergoes tyrosine phosphorylation, which is essential for its function in signaling pathways that guide the positioning of neurons. This phosphorylation allows Dab1 to interact with other proteins, notably through its PTB-like domain, facilitating its role in the Reelin signaling pathway. Reelin, a secreted protein, is vital for the proper migration and layering of neurons in the brain, and Dab1 acts downstream of Reelin, mediating its effects. Mutations in Dab1 can lead to significant brain abnormalities, mirroring the defects observed in Reelin mutants, underscoring the importance of Dab1 in maintaining neural architecture and function. |
| Product Image Gallery | |
 Western blot analysis of extracts on LOVO cells, using Phospho-Dab1 (Tyr232) Rabbit Polyclonal Antibody (EAB10715) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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