| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 40 | Human, Mouse, Rat, Monkey |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-CXCR4 (Ser339) Rabbit Polyclonal Antibody detects endogenous levels of CXCR4 protein only when phosphorylated at Ser339. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CXCR4 also known as CD184, Fusin is a CXC chemokine receptor specific for stromal cell-derived factor-1. CXCR4 is a seven-transmembrane G protein-coupled receptor that resides primarily on the cell surface. CXCR4 is highly expressed in various tissues and plays a critical role in cellular signaling, particularly in immune and developmental processes. CXCR4 interacts with stromal cell-derived factor-1 (SDF-1) to mediate chemotactic migration of immune cells such as T cells and monocytes. CXCR4′s cell surface location enables efficient detection and response to extracellular signals, guiding cell movement during immune responses, tissue repair, and development. CXCR4′s localization to the plasma membrane facilitates a role as a major co-receptor for T-tropic HIV-1, aiding in viral entry into host cells, while SDF-1 acts as an inhibitor of HIV-1 infection, highlighting significance in antiviral research. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEc cells treated with Etoposide, using Phospho-CXCR4 (Ser339) Rabbit Polyclonal Antibody (EAB10623) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
|
