| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IF/ICC, ELISA | 87 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-TrkA (Tyr496) Rabbit Polyclonal Antibody detects endogenous levels of TrkA protein only when phosphorylated at Tyr496. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TrkA also known as Trk gp140, NTRK1 is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. TrkA is primarily located on the surface of neurons, where TrkA mediates the effects of neurotrophic factors that promote neuronal health and function. NGF binding to TrkA initiates a cascade of intracellular signaling pathways that lead to neuronal survival and the modulation of synaptic plasticity, which is vital for learning and memory. TrkA′s interaction with other proteins, such as phospholipase C-gamma and the Ras-MAPK pathway, underscores TrkA′s importance in neurodevelopment and neuroprotection. |
| Product Image Gallery | |
 Western blot analysis of extracts on A549, HEK293, MCF7, HepG2 cells, using Phospho-TrkA (Tyr496) Rabbit Polyclonal Antibody (EAB10577) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
Predicted band size: 87 kDa; Observed band size: 87/140-180 kDa |
