| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 200 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Tuberin/TSC2 (Tyr1571) Rabbit Polyclonal Antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Tyr1571. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TSC2 also known as Tuberin is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. TSC2plays a crucial role in the regulation of cell growth and proliferation, making tuberin vital for maintaining cellular homeostasis. Tuberin is primarily localized in membrane fractions, where tuberin interacts with various signaling pathways, including the Ras signaling cascade, to modulate the intrinsic GTPase activity of Rap1A. This interaction is significant because tuberin helps control cellular responses to growth factors and stress, thereby influencing tumorigenesis and other cellular processes. Mutations in the TSC2 gene, which encodes tuberin, are associated with tuberous sclerosis, a genetic disorder characterized by the formation of benign tumors and neurological issues. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells, using Phospho-Tuberin/TSC2 (Tyr1571) Rabbit Polyclonal Antibody (EAB10571) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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