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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 97 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-PKD2/PRKD2 (Ser876) Rabbit Polyclonal Antibody detects endogenous levels of PKD2/PRKD2 only when phosphorylated at Ser876. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PRKD2 also known as Protein kinase D2, PKD2 is a serine/threonine protein kinase. PRKD2 plays a crucial role in various cellular processes, including proliferation, apoptosis, and signal transduction, by acting as a calcium-independent, phospholipid-dependent protein kinase. PRKD2 is primarily located in both the cytoplasm and nucleus, where PRKD2 shuttles between these compartments to exert functions. Nuclear translocation of PRKD2 facilitates transcriptional activation of key genes such as Nur77 while simultaneously excluding histone deacetylase 7 (HDAC7) from the nucleus. This dynamic localization underscores PRKD2′s significance in regulating gene expression in response to extracellular signals, particularly those mediated by G-protein-coupled receptors. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3 cells treated with PMA, using Phospho-PKD2/PRKD2 (Ser876) Rabbit Polyclonal Antibody (EAB13669) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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