| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 124 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PDGF Receptor β Rabbit Polyclonal Antibody detects endogenous levels of PDGF Receptor β protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PDGF Receptor β also known as PDGFR beta, PDGFRB is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. PDGF Receptor β plays a crucial role in cell signaling, particularly in the regulation of cell growth, survival, and migration, which are vital processes in tissue repair and development. PDGFR-β is primarily located on the surface of mesenchymal and glial cells, where PDGFR-β mediates the effects of its ligand, PDGF-BB, leading to receptor dimerization and activation of downstream signaling pathways. PDGFR-β′s ability to bind specifically to the B subunit of PDGF is essential for its function, as PDGFR-β triggers a cascade of intracellular events that influence cellular behavior. Dysregulation of PDGFR-β signaling has been implicated in various pathologies, including chronic myelomonocytic leukemia (CMML), highlighting PDGFR-β′s importance as a therapeutic target in cancer treatment. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562 cells, using PDGF Receptor β Rabbit Polyclonal Antibody (EAB10418) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using PDGF Receptor β Rabbit Polyclonal Antibody (EAB10418)at 1:100 dilution.
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