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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 37 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Mcl-1 Rabbit Polyclonal Antibody detects endogenous levels of Mcl-1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Mcl-1 also known as Myeloid cell leukemia-1, Mcl1, Gm52627 is a critical anti-apoptotic protein within the B-cell lymphoma 2 (Bcl-2) family that plays a vital role in regulating cell survival by inhibiting apoptosis through interactions with pro-apoptotic proteins like Bak and Bax, thereby preventing mitochondrial outer membrane permeabilization and cytochrome c release, essential steps in the intrinsic apoptotic pathway. Mcl-1 functions to ensure normal development, tissue homeostasis, and immune system function, particularly in the maintenance of B and T lymphocyte populations. Dysregulation or overexpression of Mcl-1 can lead to the survival of abnormal cells and has been implicated in the development of various cancers, including leukemia, lymphoma, and solid tumors, making Mcl-1 an important target for cancer research and therapeutic intervention. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat, NIH/3T3, HepG2 cells, using Mcl-1 Rabbit Polyclonal Antibody (EAB10408) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue, using Mcl-1 Rabbit Polyclonal Antibody (EAB10408) at 1:100 dilution.
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