| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 150 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PLCβ3 Rabbit Polyclonal Antibody detects endogenous levels of PLCβ3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PLCβ3 also known as PLCB3 is a member of the phosphoinositide phospholipase C beta enzyme family. PLCβ3 plays a vital role in cellular signaling pathways by catalyzing the hydrolysis of phosphatidylinositol 4, 5-bisphosphate into inositol 1, 4, 5-trisphosphate and diacylglycerol, which are crucial second messengers in regulating various physiological processes, including cell growth, differentiation, and apoptosis. PLCβ3 is predominantly located in the plasma membrane, where PLCβ3 interacts with G protein-coupled receptors and is activated by Gq class heterotrimeric G proteins, highlighting its importance in mediating receptor signaling. PLCβ3 presence in various tissues underscores its significance in both normal physiology and pathological conditions, making PLCβ3 a valuable target for research and therapeutic applications. |
| Product Image Gallery | |
 Western blot analysis of extracts on A431, HepG2 cells, using PLCβ3 Rabbit Polyclonal Antibody (EAB10357) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry of paraffin-embedded Human brain tissue, using PLCβ3 Rabbit Polyclonal Antibody (EAB10357) at 1:100 dilution.
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