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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 80 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-IKKε (Ser172) Rabbit Polyclonal Antibody detects endogenous levels of IKKε protein only when phosphorylated at Ser172. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IKKε also known as IKBKE, IKKI is a serine/threonine kinase that plays a crucial role in immune response by regulating the activation of transcription factor NFκB. IKKε is primarily expressed in immune cells and is induced by stimuli such as lipopolysaccharide and proinflammatory cytokines like TNFα, IL-1, and IL-6. IKKε is essential for phosphorylation of IκBα at specific serine residues, which leads to degradation of IκB and subsequent release and activation of NFκB. IKKε′s ability to modulate NFκB signaling is significant, as NFκB is involved in various cellular processes, including inflammation, immune response, and cell survival. Overexpression of IKKε has been linked to enhanced phosphorylation of IκBα and increased NFκB activity, indicating a potential role as an IκB kinase in immune regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using Phospho-IKKε (Ser172) Rabbit Polyclonal Antibody (EAB14473) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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