Protein Inhibitors - NU 7441 (CAS: 503468-95-9)

NU 7441 (CAS: 503468-95-9)

Catalog #：EBC51169

Biological Activity

Synonyms

KU-57788, KU 57788

Chemical Name

8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one

Application

NU7441 is a potent novel DNA-PK inhibitor

CAS Number

503468-95-9

Purity

≥98.0%

Molecular Weight

413.49

Molecular Formula

C₂₅H₁₉NO₃S

SMILES

C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56

Target & IC50

DNA-PK: IC50 = 14 nM
PI3K : IC50 = 5 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4184 ml	12.0922 ml	24.1844 ml
5 mM	0.4837 ml	2.4184 ml	4.8369 ml
10 mM	0.2418 ml	1.2092 ml	2.4184 ml
50 mM	0.0484 ml	0.2418 ml	0.4837 ml

Solubility
DMSO: 15 mg/mL (36.28 mM)

Product Description

NU 7441 is a selective and potent DNA-PK inhibitor (IC50 14nM) and P13K inhibitor (IC50 5uM). It is reported enhance the cytotoxic effects of radiation in cancer cell lines and potentiate the effects of etoposide and doxorubicin. NU 7441 is also reported to enhance the efficiency of CRISPR-Cas9 mediated homology-directed repair (HDR) 2 to 4 fold and decrease nonhomologous end-joining (NHEJ) frequency by 2 fold.