Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | Nocodazolum, ChEMBL9514, Oncodazole, | ||||||||||||||||||||||||
| Chemical Name | methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate | ||||||||||||||||||||||||
| Application | Nocodazole is a potent Tubulin production inhibitor, anti-neoplastic agent, and inhibitor of mitosis | ||||||||||||||||||||||||
| CAS Number | 31430-18-9 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 301.32 | ||||||||||||||||||||||||
| Molecular Formula | C₁₄H₁₁N₃O₃S | ||||||||||||||||||||||||
| SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3 | ||||||||||||||||||||||||
| Target & IC50 | Abl: IC50 = 0.21μM | ||||||||||||||||||||||||
| Shipping | Room Temperature | ||||||||||||||||||||||||
| Storage | Room Temperature | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 20 mg/mL (66.37 mM) |
| Product Description | |
Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl (E255K) and Abl (T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. Nocodazole will bind to β-Tb and block polymerization, arrest mammalian cells in mitosis and release them into cytokinesis and G1 as well as mis-regulate mitotic kinases. |
