Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | MK 886,MK886, L663536 | ||||||||||||||||||||||||
| Chemical Name | 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid . Na | ||||||||||||||||||||||||
| Application | MK-886 sodium salt is a potent and selective inhibitor of FLAP and Cox-1 | ||||||||||||||||||||||||
| CAS Number | 118427-55-7 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 494.06 | ||||||||||||||||||||||||
| Molecular Formula | C₂₇H₃₃ClNO₂S•Na | ||||||||||||||||||||||||
| SMILES | CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)[O-])CC3=CC=C(C=C3)Cl.[Na+] | ||||||||||||||||||||||||
| Target & IC50 | leukotriene: IC50 = 2.5 nM leukotriene: IC50 = 1.1 μM |
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| Shipping | Room Temperature | ||||||||||||||||||||||||
| Storage | Room Temperature | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 25 mg/mL (50.6 mM) Ethanol: 25 mg/mL (50.6 mM) |
| Product Description | |
MK-886 sodium salt, also designated L-663,536, is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP). FLAP is an arachidonic acid binding protein that is critical in the biosynthesis of leukotrienes. Inhibitors of FLAP prevent translocation of 5-lipoxygenase from the cytosol to the membrane and inhibit 5-lipoxygenase (5-LO) activation. MK-886 binds to FLAP with high affinity and prevents the activation of 5-LO, thus inhibiting leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. MK-886 sodium salt is an inhibitor of Cox-1, PGE Synthase and PPARα. |
