Protein Inhibitors - LY 411575 (CAS: 209984-57-6)

LY 411575 (CAS: 209984-57-6)

Catalog #：EBC51139

Biological Activity

Synonyms

LY-411575, LY411575

Chemical Name

(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

Application

LY411575 is a potent γ-secretase inhibitor

CAS Number

209984-57-6

Purity

≥98.0%

Molecular Weight

479.48

Molecular Formula

C₂₆H₂₃F₂N₃O₄

SMILES

C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O

Target & IC50

γ-secretase IC50: = 0.078 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.0856 ml	10.4280 ml	20.8559 ml
5 mM	0.4171 ml	2.0856 ml	4.1712 ml
10 mM	0.2086 ml	1.0428 ml	2.0856 ml
50 mM	0.0417 ml	0.2086 ml	0.4171 ml

Solubility
DMSO: 88 mg/mL (183.5 mM) Ethanol: 11 mg/mL (22.9 mM)

Product Description

γ-Secertase is one of intramenbrane-cleaving aspartyl protease which cleaves many type-I membrane proteins and many of them have important biological functions. γ-Secretase is a multi-subunit protease and it contains presenilin, nicastrin, APH-1(Anterior Pharynx- defective 1) and PEN-2. Presenilin contains Asp258 and Asp385 embedded in the sixth and seventh transmembrane domain and forms the active site. The feature of being a membrane integrated protease complex makes it difficult to be purified as well as studying its mechanism.γ-secretase is responsible for the generation Aβfrom the amyloid precursor protein.γ-Secertase has been considered as an important drug target for Alzheimer's disease.γ-Secertase also is responsible for Notch processing which is related to cancer such as leukemia.