Protein Inhibitors - LY 294002 (CAS: 154447-36-6)

LY 294002 (CAS: 154447-36-6)

Catalog #：EBC51137

Biological Activity

Synonyms

LY294002, LY-294002

Chemical Name

2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one

Application

LY 294002 is a potent blocker of PI 3-kinase/Akt signaling

CAS Number

154447-36-6

Purity

≥98.0%,

Molecular Weight

307.34

Molecular Formula

C₁₉H₁₇NO₃

SMILES

C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4

Target & IC50

Purified PI3K: IC50 = 1.4 μM
Pim-1 kinase : IC50 = 4.0 μM
p110α: IC50 = 0.63 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.2537 ml	16.2686 ml	32.5373 ml
5 mM	0.6507 ml	3.2537 ml	6.5075 ml
10 mM	0.3254 ml	1.6269 ml	3.2537 ml
50 mM	0.0651 ml	0.3254 ml	0.6507 ml

Solubility
DMSO: 34 mg/mL (110.6 mM) Ethanol: 10 mg/mL (32.5 mM)

Product Description

LY 294002 is a potent inhibitor of PI 3-kinase, a protein in the phosphoinositide 3-kinase family of intercellular signal regulating enzymes. This compound is selective for PI 3-kinase p110 β (PI 3-Kβ) and PI 3-kinase p110 α (PI 3-Kα), although it will inhibit other PI 3 kinases at higher concentrations (IC50 = 310 nM and 730 nM for PI 3-Kβ and PI 3-Kα, respectively). The pathway associated with these receptors is implicated in cancer and diabetes, and LY294002 is an important tool for studying this relationship. Reports indicate that LY294002 encourages apoptosis in such cells by blocking the PI 3-kinase/Akt signaling pathway which has been strongly related to cancer survival and proliferation. LY 294002 is an inhibitor of Pim-1, PI 3-kinase p110 δ and PI 3-kinase p110 γ.