Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | LY 2157299, LY-2157299, Galunisertib | ||||||||||||||||||||||||
| Chemical Name | 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide | ||||||||||||||||||||||||
| Application | LY2157299 is a potent TGF β RI inhibitor | ||||||||||||||||||||||||
| CAS Number | 700874-72-2 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 369.42 | ||||||||||||||||||||||||
| Molecular Formula | C₂₂H₁₉N₅O | ||||||||||||||||||||||||
| SMILES | CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N | ||||||||||||||||||||||||
| Target & IC50 | Flk-1: IC50 = 442 nM TGFβ RI: IC50 = 56 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 74 mg/mL (200.31 mM) |
| Product Description | |
LY 2157299 is a potent inhibitor of Transforming Growth factor-Beta Receptor I (TGF-BetaR). TGF-Beta1 is involved in the control of cell growth, proliferation, differentiation, and apoptosis. LY2157299 is reported to disrupt Smad-2 phosphorylation in Human Umbilical Vein Endothelial Cells (HUVEC) and inhibit the growth and migration of tumor cells. |
