| Biological Activity | |||||||||||||||||||||||||
| Synonyms | LDN-193189 hydrochloride, LDN193189 HCl | ||||||||||||||||||||||||
| Chemical Name | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | ||||||||||||||||||||||||
| Application | LDN 193189 HCl is a selective BMP signaling inhibitor | ||||||||||||||||||||||||
| CAS Number | 1062368-62-0 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 442.94 | ||||||||||||||||||||||||
| Molecular Formula | C₂₅H₂₂N₆ HCl | ||||||||||||||||||||||||
| SMILES | C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl | ||||||||||||||||||||||||
| Target & IC50 | ALK2: IC50 = 5 nM ALK3: IC50 = 30 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 55.23mg/ml （100 mM） |
| Product Description | |
LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification. The salt-based form of LDN193189 has higher solubility in DMSO than LDN193189 |
