Other Biochemicals - LDN 193189 (CAS: 1062368-24-4)

LDN 193189 (CAS: 1062368-24-4)

Catalog #：EBC51133

Biological Activity

Synonyms

LDN 193189, LDN-193189, DM-3189

Chemical Name

4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Application

LDN193189 is a selective transcriptional activity morphogenetic protein (BMP) type I receptors inhibitor

CAS Number

1062368-24-4

Purity

≥98.0%

Molecular Weight

406.48

Molecular Formula

C₂₅H₂₂N₆

SMILES

C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3

Target & IC50

ALK2: IC50 = 5 nM
ALK3: IC50 = 30 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4601 ml	12.3007 ml	24.6015 ml
5 mM	0.4920 ml	2.4601 ml	4.9203 ml
10 mM	0.2460 ml	1.2301 ml	2.4602 ml
50 mM	0.0492 ml	0.2460 ml	0.4920 ml

Solubility
DMSO : 12 mg/mL (29.52 mM; ultrasonic and adjust pH to 2 with HCl) Ethanol : 1 mg/mL (2.46 mM; Need ultrasonic)

Product Description

LDN 193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 (IC₅₀≥ 500 nM). It inhibits the activation of the BMP signaling effectors SMAD1, SMAD5 and SMAD8 in a dose-dependent manner in C2C12 cells. LDN-193189 significantly reduces tumor growth in SCID mice bearing MDA-PCa-118b tumors