Other Biochemicals - L-755,507 (CAS: 159182-43-1)

L-755,507 (CAS: 159182-43-1)

Catalog #：EBC51131

Biological Activity

Synonyms

L 755507, L755507

Chemical Name

4-(Hexylamino)carbonylamino-N-4-2-(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propylaminoethylphenyl-benzenesulfonamide

Application

L-755,507 is a very potent, selective β3-adrenergic receptor partial agonist

CAS Number

159182-43-1

Purity

≥99.0%

Molecular Weight

584.73

Molecular Formula

C₃₀H₄₀N₄O₆S

SMILES

CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNC[C@@H](COC3=CC=C(C=C3)O)O

Target & IC50

β3-AR: IC50 = 35 nM

Shipping

Room Temperature

Storage

Room Temperature

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.7102 ml	8.5510 ml	17.1019 ml
5 mM	0.3420 ml	1.7102 ml	3.4204 ml
10 mM	0.1710 ml	0.8551 ml	1.7102 ml
50 mM	0.0342 ml	0.1710 ml	0.3420 ml

Solubility
DMSO: 58.5 mg/mL (100 mM) Ethanol: 58.5 mg/mL (100 mM)

Product Description

L-755,507 is a very potent and selective β3-adrenergic receptor partial agonist, selective over both β1- and β2-adrenoceptor binding. In fact, L-755,507 displays more than 440-fold selectivity for β3- over β1- and β2-adrenoceptors (EC50s = 580 and >10,000 nM, respectively). L-755,507 is used to assess β3 agonists. To identify signaling pathways activated through β3-adrenergic receptors, L-755,507 can be used.