Protein Inhibitors - Stattic (CAS: 19983-44-9)

Stattic (CAS: 19983-44-9)

Catalog #：EBC51124

Biological Activity

Synonyms

STAT3 inhibitor

Chemical Name

6-Nitrobenzo[b]thiophene-1,1-dioxide

Application

Stat3 inhibitor V, stattic is an inhibitor of Stat3 activation

CAS Number

19983-44-9

Purity

≥99.0%

Molecular Weight

211.19

Molecular Formula

C₈H₅NO₄S

SMILES

C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

Target & IC50

STAT3: IC50 = 5.1μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.7351 ml	23.6754 ml	47.3507 ml
5 mM	0.9470 ml	4.7351 ml	9.4701 ml
10 mM	0.4735 ml	2.3675 ml	4.7351 ml
50 mM	0.0947 ml	0.4735 ml	0.9470 ml

Solubility
DMSO: 42 mg/mL (198.87 mM)

Product Description

Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines, and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3.