Photo：010-62890160
| Biological Activity | |
| Synonyms | Inhibitor of Wnt Production-3, IWP3, IWP 3 |
| Chemical Name | 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide |
| Application | IWP-3 is an inhibitor of Wnt production |
| CAS Number | 687561-60-0 |
| Purity | ≥98.0% |
| Molecular Weight | 484.59 |
| Molecular Formula | C₂₂H₁₇FN₄O₂S₃ |
| SMILES | O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=C(F)C=C5)=O |
| Target & IC50 | Wnt: IC50 = 40 nM |
| Shipping | Gel Pack |
| Storage | Store at -20°C |
| Solubility | |
| DMSO: 2 mg/ml |
| Product Description | |
IWP-3 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells. |
