Protein Inhibitors - IWP-2 (CAS: 686770-61-6)

IWP-2 (CAS: 686770-61-6)

Catalog #：EBC51120

Biological Activity

Synonyms

IWP 2, IWP2

Chemical Name

N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3- phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide

Application

IWP-2 is an inhibitor of Wnt production

CAS Number

686770-61-6

Purity

≥99.0%

Molecular Weight

466.60

Molecular Formula

C₂₂H₁₈N₄O₂S₃

SMILES

CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

Target & IC50

Wnt: IC50 = 27 nM
CK1δ: IC50 = 40 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.1432 ml	10.7158 ml	21.4316 ml
5 mM	0.4286 ml	2.1432 ml	4.2863 ml
10 mM	0.2143 ml	1.0716 ml	2.1432 ml
50 mM	0.0429 ml	0.2143 ml	0.4286 ml

Solubility
DMSO : 2 mg/mL (4.29 mM)

Product Description

IWP-2 is an inactivator of Porcn function, and inhibitor of Wnt production. The Wnt/b-catenin (′canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to the disease stage. IWP-2 inhibits Wnt production. It appears that IWP-2 inactivates Porcn function either by modulating the function of a Porcn regulator or by directly inhibiting the Porcn active site. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 has been used to suppress embryonic stem cell self-renewal.