Protein Inhibitors - SB 203580 (CAS: 152121-47-6)

SB 203580 (CAS: 152121-47-6)

Catalog #：EBC51118

Biological Activity

Synonyms

RWJ 64809, PB 203580,p38 MAPK inhibitor

Chemical Name

4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine

Application

SB 203580 is a pyridinyl imidazole and specific inhibitor that suppresses p38 mediated activation of MK2

CAS Number

152121-47-6

Purity

≥99.0%

Molecular Weight

377.43

Molecular Formula

C₂₁H₁₆FN₃OS

SMILES

CS(=O)c1ccc(cc1)c2nc(c(n2)c3ccncc3)c4ccc(F)cc4

Target & IC50

SAPK2a/p38: EC5050 = 50 nM
SAPK2b/p38β2: IC50 = 500 nM
p38 MAP kinase : IC50 = 34 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.6495 ml	13.2475 ml	26.4950 ml
5 mM	0.5299 ml	2.6495 ml	5.2990 ml
10 mM	0.2650 ml	1.3248 ml	2.6495 ml
50 mM	0.0530 ml	0.2650 ml	0.5299 ml

Solubility
DMSO: 59 mg/mL (156.32 mM)

Product Description

SB 203580 is a pyridinyl imidazole which suppresses the p38 mediated activation of MAPKAP kinase-2 (MAPKAP K2 or MK2), yet does not disrupt JNK activity. Mitogen-activated protein kinases (MAPK) are a group of serine and threonine-specific kinases sensitive to cellular stress, heat shock and proinflammatory cytokines. p38 MAPK is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 inhibits the phosphorylation of heat shock protein 27 (HSP 27). SB 203580 has been shown to induce the activation of Raf-1. SB 203580 has also been shown to prevent the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1). SB 203580 is a useful tool to assess the physiological roles of p38, and for deriving and maintaining embryonic stem cells.