Other Biochemicals - A 205804 (CAS: 251992-66-2)

A 205804 (CAS: 251992-66-2)

Catalog #：EBC51112

Biological Activity

Synonyms

A205804, A-205804

Chemical Name

4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide

Application

A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression

CAS Number

251992-66-2

Purity

≥98.0%

Molecular Weight

300.40

Molecular Formula

C₁₅H₁₂N₂OS₂

SMILES

CC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N

Target & IC50

E-selectin: IC50 = 20 nM
ICAM-1: IC50 = 25 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.3289 ml	16.6445 ml	33.2889 ml
5 mM	0.6658 ml	3.3289 ml	6.6578 ml
10 mM	0.3329 ml	1.6645 ml	3.3289 ml
50 mM	0.0666 ml	0.3329 ml	0.6658 ml

Solubility
DMSO: 30 mg/mL (100 mM)

Product Description

A 205804 is a selective E-selectin and ICAM-1 inhibitor over VCAM-1. When tested with primary HUVECs cells, A-205804 treatment reduced cell migration ability by inhibiting the expression of E-selectin and ICAM-1. In human vascular endothelial cells using whole-cell high-throughput assay, it was shown that A 205804 exhibited potent and selective inhibition to E-selectin and ICAM-1 with low concentrations. Further, it was revealed that A 205804 inhibited E-selectin and ICAM-1 expressions by translocating to cell nucleus and noncovalently associated with macromolecules of molecular weight greater than 650 kDa when tested with human umbilical vein endothelial cells (HUVECs).