Other Biochemicals - GSK 923295 (CAS: 1088965-37-0)

GSK 923295 (CAS: 1088965-37-0)

Catalog #：EBC51103

Biological Activity

Synonyms

GSK-923295

Chemical Name

3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide

Application

GSK 923295 is a specific allosteric inhibitor of CENP-E kinesin motor ATPase

CAS Number

1088965-37-0

Purity

≥99.0%

Molecular Weight

592.13

Molecular Formula

C₃₂H₃₈ClN₅O₄

SMILES

C[C@@H](C1=CC=CN2C1=NC(=C2)C3=CC=C(C=C3)C[C@@H](CNC(=O)CN(C)C)NC(=O)C4=CC(=C(C=C4)OC(C)C)Cl)O

Target & IC50

CENP-E

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.6888 ml	8.4441 ml	16.8882 ml
5 mM	0.3378 ml	1.6888 ml	3.3776 ml
10 mM	0.1689 ml	0.8444 ml	1.6888 ml
50 mM	0.0338 ml	0.1689 ml	0.3378 ml

Solubility
DMSO: 100 mg/mL (168.88 mM) Ethanol: 100 mg/mL (168.88 mM)

Product Description

GSK 923295 is a potent and selective mitotic kinesin Centromere protein E (CENP-E) inhibitor, a protein that accumulates in the G2 phase of the cell cycle. It is proposed to be one of the motors responsible for mammalian chromosome movement and spindle elongation. GSK923295 induces mitotic arrest and chromosome alignment failure. It is reported to be a potent inhibitor of tumor cell growth, which is further enhanced when MEK/ERK signaling is also inhibited.