Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | Gö 6983, Goe 6983, Gouml 6983, inhibitor | ||||||||||||||||||||||||
| Chemical Name | 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione | ||||||||||||||||||||||||
| Application | Go 6983 is a PKC inhibitor that selectively inhibits PKC isoenzymes | ||||||||||||||||||||||||
| CAS Number | 133053-19-7 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 442.50 | ||||||||||||||||||||||||
| Molecular Formula | C₂₆H₂₆N₄O₃ | ||||||||||||||||||||||||
| SMILES | CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 | ||||||||||||||||||||||||
| Target & IC50 | PKCα: IC50 = 7 nM PKCβ: IC50 = 7 nM PKCγ: IC50 = 6 nM PKCδ: IC50 = 10 nM PKCζ: IC50 = 60 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 88 mg/mL (198.87 mM) |
| Product Description | |
Go 6983 is a broad fast-acting inhibitor of various isoforms of protein kinase C. It can be used to inhibit differentiation and maintain the pluripotency of embryonic stem cells and enhance stem cell viability and growth. Go 6983 is also reported to exert cardio protective effects in myocardial ischemia and inhibited intracellular Ca accumulation. |
