Protein Inhibitors - Garcinol (CAS: 78824-30-3)

Garcinol (CAS: 78824-30-3)

Catalog #：EBC51100

Biological Activity

Synonyms

Camboginol, CCRIS 9029, p300 and PCAF inhibitor

Chemical Name

3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-5,7-bis(3-methylbut-2-enyl)-1-(5-methyl-2-prop-1-en-2-ylhex-4-enyl)bicyclo[3.3.1]nonane-2,4,9-trione

Application

Garcinol is a polyisoprenylated benzophenone derived p300 and PCAF histone acetyltransferase inhibitor

CAS Number

78824-30-3

Purity

≥95.0%

Molecular Weight

602.80

Molecular Formula

C₃₈H₅₀O₆

SMILES

CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C

Target & IC50

Histone acetyltransferases (HATs) p300: IC50 = 7 μM
PCAF: IC50 = 5 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.6589 ml	8.2946 ml	16.5893 ml
5 mM	0.3318 ml	1.6589 ml	3.3179 ml
10 mM	0.1659 ml	0.8295 ml	1.6589 ml
50 mM	0.0332 ml	0.1659 ml	0.3318 ml

Solubility
DMSO: 20 mg/mL (33.18 mM) Ethanol: 20 mg/mL (33.18 mM)

Product Description

Garcinol is a polyisoprenylated benzophenone derivative and a potent inhibitor of histone acetyltransferases (HATs) PCAF and p300. It has been used to inhibit the growth of cancer cell lines and to promote ex vivo expansion of human stem cells. Garcinol also exhibits antioxidative and chelating activity and is reported to induce apoptosis in HeLa cells by downregulating their global gene expression.